Abstract
Objectives Our objective was to evaluate the trend and to assess the impact of maternal region
of residence in Western New York (WNY), on severe neonatal opioid withdrawal syndrome
(NOWS).
Study Design Term infants' born at gestational age greater than or equal to 37 weeks with severe
NOWS, defined as withdrawal resulting in the receipt of pharmacologic therapy from
WNY admitted to our neonatal intensive care unit (NICU) from January 1, 2008 to December
31, 2016, were included. Severe NOWS admissions to our NICU from the following five
regions were controlled with birth and insurance data: (1) Urban North, (2) Erie Coastal,
(3) Niagara Frontier, (4) Southern Tier, and (5) Urban South.
Results “Urban South” residence was associated with an increased risk of severe NOWS (adjusted
odds ratio = 1.8, 97.5% confidence interval: 1.1–2.9). The trend in admission for
severe NOWS doubled between 2008 to 2010 and 2014 to 2016 (p = 0.01). More infants born to maternal nonprescribed opioid users were placed in
foster care at discharge (36.5 vs. 1.9%, p < 0.001).
Conclusion In WNY, neonates born to mothers from the “Urban South” were twice at risk of being
admitted for severe NOWS. One-third of infants with severe NOWS after nonprescribed
opioid use were placed in foster care. Implementing targeted strategies at the community
level may help improve outcomes in NOWS.
Key Points
-
Maternal region of residence is a risk factor for severe neonatal opioid withdrawal.
-
Admissions for severe neonatal opioid withdrawal trended up from 2008 to 2010 to 2014
to 2016.
-
One-third of the infants born to mothers on nonprescribed opioids were discharged
to foster care.
Keywords
severe neonatal opioid withdrawal syndrome - region of residence - neonatal intensive
care unit - trends in severe NOWS
